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Human KCNJ2 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0024
Background
Kir2.1 has a fundamental role in controlling the resting potential of cardiac myocytes and shaping the cardiac action potential. It is therefore likely that drugs affecting this channel will have an effect on cardiac excitability. Mutations in the KCNJ2 gene that encodes Kir2.1, reduce expression of the channel and cause a form of long QT syndrome that predisposes individuals to ventricular arrhythmias. Recognition that the dysfunction of this channel can lead to long QT has lead to it’s inclusion into the cardiac panel.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
KCNJ2
Synonyms
KCNJ2; potassium inwardly-rectifying channel, subfamily J, member 2; inward rectifier potassium channel 2; IRK1; Kir2.1; IRK-1; hIRK1; inward rectifier K+ channel KIR2.1; cardiac inward rectifier potassium channel; LQT7; SQT3; ATFB9; HHIRK1; KIR2.1; HHBIRK1;
Gene ID
MIM
UniProt ID
P63252
Chromosome Location
17q24.3
Pathway
Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Classical Kir channels, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem;
Function
inward rectifier potassium channel activity; voltage-gated ion channel activity;
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Cat#
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Titer
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AD08425Z
>1x 10^9 vp/ml
1 x 0.2 ml
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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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