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Human HTR6/Galpha15 Stable Cell Line-Chem-10

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Cat.No.
CSC-RG0755
Background
The neurotransmitter serotonin/5-hydroxytryptamine (5-HT) regulates a wide variety of neurological functions. A family of 13 receptors (12 GPCRs and one ion channel) mediate the effects of serotonin. The serotonin receptor 5-HT6 is a Gs coupled receptor expressed solely in the CNS, primarily in the limbic and cortical regions. 5-HT6 appears to play a role in memory and learning, obesity, psychosis, anxiety and epilepsy. In particular, a 5-HT6-selective agonist caused significant weight loss in a rat model of diet-induced obesity.
Growth Properties
Adherent
Host Cell
Chem-10
Ship
Dry ice
Gene Information
Official Symbol
HTR6
Synonyms
HTR6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 6; 5-hydroxytryptamine receptor 6; 5 HT6; 5 HT6R; 5-HT-6; serotonin receptor 6; 5-HT6; 5-HT6R;
Gene ID
MIM
UniProt ID
P50406
Chromosome Location
1p36-p35
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled receptor activity; histamine receptor activity; protein binding; receptor activity; signal transducer activity;

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