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Human HTR2C/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0753
Background
5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT2C, which couples to Gq in most cells to stimulate intracellular calcium, is prominently expressed in brain and appears to modulate depression, anxiety and appetite. The mRNA encoding 5-HT2C undergoes selective RNA editing that changes 4 amino acids in the second intracellular loop; these changes result in alteration of efficiency of coupling to G proteins. Alterations in editing of 5-HT2C have been detected in victims of suicidal depression and in mice treated with the SSRI, fluoxetine.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
HTR2C
Synonyms
HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 2C , HTR1C; 5-hydroxytryptamine receptor 2C; 5 HT2C; 5-HT1C; 5-HT-1C; 5-HT-2C; serotonin receptor 2C; serotonin 5-HT-2C receptor; 5-hydroxytryptamine receptor 1C; HTR1C; 5-HT2C; 5-HTR2C;
Gene ID
MIM
UniProt ID
P28335
Chromosome Location
Xq23
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; G-protein coupled receptor activity; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; serotonin binding; serotonin receptor activity; signal transducer activity;

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