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Human HTR2B/Galpha15 Stable Cell Line-CHO

Cat.No.
CSC-RG0752
Abbr
CHO -HuHTR2B/Galpha15
Alias
HTR2B,5 HT(2B),5 HT2B,5-HT-2B,5-HT2B,5-HT(2B)
Growth Properties
Adherent
Host Cell
CHO
Morphology
Epithelial-like
Shipping
Dry ice
Background
5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. The 5-HT2B receptor, which couples to Gq/11 to increase intracellular calcium, is expressed in embryonic and adult cardiovascular tissues, gut and brain from the rat, mouse, and human species. A role for 5-HT2B receptors was suggested in the cardiopathy associated with fenfluramine.

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