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Human HTR1A/Galpha15 Stable Cell Line-Chem-3

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Cat.No.
CSC-RG0750
Background
5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT1A has been implicated in anxiety and depression. Desensitization of 5-HT1A has been correlated with the functional improvements in depression observed 2-3 weeks after initiation of treatment with SSRIs. Decreased 5-HT1A is observed in anxiety disorders, and mice lacking 5-HT1A display increased anxiety. Buspirone, a partial agonist for 5-HT1A , is used clinically for treatment of anxiety disorders.
Growth Properties
Adherent
Host Cell
Chem-3
Ship
Dry ice
Gene Information
Official Symbol
HTR1A
Synonyms
HTR1A; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 1A , ADRB2RL1, ADRBRL1; 5-hydroxytryptamine receptor 1A; 5 HT1A; 5-HT1a receptor; serotonin receptor 1A; G protein coupled receptor; guanine nucleotide-binding regulatory protein-coupled receptor; G-21; 5HT1a; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1;
Gene ID
MIM
UniProt ID
P08908
Chromosome Location
5q11.2-q13
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Monoamine GPCRs, organism-specific biosystem;
Function
G-protein coupled receptor activity; drug binding; receptor activity; serotonin binding; serotonin receptor activity; signal transducer activity;

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