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Human HRH4/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1292
Background
Histamine is one of the most studied biomolecules in medicine and is most notably known for its effects on smooth muscle contraction, vascular permeability and regulation of stomach acid. The histamine receptor H4 has been shown to have a role in chemotaxis and mediator release in a variety of immune cells, such as mast cells, eosinophils, dendritic cells, and T cells. The development of potent H4 receptor antagonists has great potential to open up the pathway for new therapeutic treatments in chronic inflammatory diseases, such as bronchial asthma, allergic gastrointestinal disease, and atopic dermatitis.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
HRH4
Synonyms
HRH4; histamine receptor H4; histamine H4 receptor; AXOR35; GPCR105; GPRv53; H4R; HH4R; SP9144; pfi-013; G-protein coupled receptor 105; H4; BG26; MGC133027;
Gene ID
MIM
UniProt ID
Q9H3N8
Chromosome Location
18q11.2
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Histamine receptors, organism-specific biosystem;
Function
G-protein coupled receptor activity; histamine receptor activity; receptor activity; signal transducer activity;

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