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Human HRH2-FLAG Stable Cell Line-HEK293T

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Cat.No.
CSC-RG0274
Background
Histamine is one of the most studied biomolecules in medicine and is most notably known for its effects on smooth muscle contraction, vascular permeability and regulation of stomach acid. H2 receptors are positively coupled to adenylate cyclase via Gs. It increases the intracellular Ca2+ concentrations and release Ca2+ from intracellular stores by coupling to Gq. H2 receptors have been found to be located in a variety of tissues, including the brain, gastric cells, and cardiac tissue. Histamine H2 receptors have a potent effect on gastric acid secretion, and the inhibition of this secretory process by H2 receptor antagonists has provided evidence for an important physiological role of histamine in the regulation of gastric secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. It has also been demonstrated to control the relaxation of smooth muscles.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T
Ship
Dry ice
Gene Information
Official Symbol
HRH2
Synonyms
HRH2; histamine receptor H2; histamine H2 receptor; HH2R; gastric receptor 1; gastric receptor I; H2R;
Gene ID
MIM
UniProt ID
P25021
Chromosome Location
5q35
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled receptor activity; histamine receptor activity; receptor activity; signal transducer activity;

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