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Human HRH1-FLAG Stable Cell Line-HEK293T

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Cat.No.
CSC-RG0273
Background
Histamine H1 receptor (H1 or HRH1) is a subclass of histamine receptors. It mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, and neurotransmission in the central nervous system. Antihistamines including H1 receptor antagonists are among the most frequently used pharmacologic agents because of a high incident rate of upper respiratory allergies. Clinical and laboratory evidence on histamine and its actions suggests that it has a pathophysiologic role in asthma. These findings have renewed interest in the potential therapeutic role of H1-receptor antagonists, such as, fexofenadine, which has been investigated as potential therapeutic targets for this disease.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T
Ship
Dry ice
Gene Information
Official Symbol
HRH1
Synonyms
HRH1; histamine receptor H1; histamine H1 receptor; H1R; HH1R; histamine H receptor; histamine receptor, subclass H1; H1-R; hisH1;
Gene ID
MIM
UniProt ID
P35367
Chromosome Location
3p25
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled receptor activity; histamine binding; histamine receptor activity; receptor activity; signal transducer activity;

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