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Human HCRTR1/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0713
Background
The orexin/hypocretin peptides orexin A and orexin B (also known as hcrt-1 and hcrt-2) are 33- and 28-amino acid peptides, respectively, that are preferentially expressed in hypothalamus. The orexins bind to two GPCRs, OX1 and OX2 , to increase intracellular calcium. Experiments with OX1 selective antagonists have shown the receptor plays a role in food consumption and also in acquisition and consolidation of spatial memory. In addition, the orexinergic system plays a role in energy metabolism and stress responses.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
HCRTR1
Synonyms
HCRTR1; hypocretin (orexin) receptor 1; orexin receptor type 1; OX1R; ox1-R; ox-1-R; orexin receptor 1; orexin receptor-1; hypocretin receptor 1; hypocretin receptor-1; hypocretin receptor type 1;
Gene ID
MIM
UniProt ID
O43613
Chromosome Location
1p33
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; orexin receptor activity; peptide hormone binding; receptor activity; signal transducer activity;

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