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Human HCAR3/beta-Arrestin Stable Cell Line-CHO

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Cat.No.
CSC-RG1517
Background
GPR109B (or HM74) is a 387-amino acid, 7-transmembrane protein responsible for the directed migration of specific cell types. GPR109B has highest expression in spleen, lymphocytes and adipose tissue, and lower expression in the heart, placenta, prostate and bone marrow. Nicotinic acid has been used as a lipid-lowering agent possibly by acting through GPR109A and GPR109B in adipose tissues. This supports the suggestion that signaling through this nicotinic acid receptors may be a mechanism for the treatment of hyperlipidemia and insulin-resistant states.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
HCAR3
Synonyms
HCAR3; hydroxycarboxylic acid receptor 3; G protein coupled receptor 109B , GPR109B; HCA3; HM74; niacin receptor 2; GTP-binding protein; nicotinic acid receptor 2; putative chemokine receptor; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; hydroxy-carboxylic acid receptor 3; PUMAG; Puma-g; GPR109B;
Gene ID
MIM
UniProt ID
P49019
Chromosome Location
12q24.31
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;
Function
G-protein coupled purinergic nucleotide receptor activity; G-protein coupled receptor activity; receptor activity; signal transducer activity;

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