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Human HCAR2/beta-Arrestin Stable Cell Line-CHO

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Cat.No.
CSC-RG1516
Background
delta opioid receptor (DOR) inhibits neurotransmitter release by reducing Ca2+ currents and increasing K+ conductance. In rats, morphine tolerance is associated with DOR-mediated activation of cortical CCKergic systems. There are indications that some DOR antagonists produce potent antitussive effects and may be considered as candidates of antitussive drugs. In contrast, some DOR agonists have shown antinociceptive, seizuregenic and convulsive properties, implicating a role for the DOR in depression. Early clinical experiments have demonstrated that exogenously administered opioid peptides had antidepressant activity in human patients, suggesting that the receptor may provide a new therapeutic target for treating depression.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
HCAR2
Synonyms
HCAR2; hydroxycarboxylic acid receptor 2; G protein coupled receptor 109A , GPR109A; HCA2; HM74A; niacin receptor 1; NIACR1; Puma g; PUMAG; nicotinic acid receptor; G protein-coupled receptor 109A; G-protein coupled receptor 109A; G protein-coupled receptor HM74a; G-protein coupled receptor HM74A; hydroxy-carboxylic acid receptor 2; HM74a; HM74b; Puma-g; GPR109A;
Gene ID
MIM
UniProt ID
Q8TDS4
Chromosome Location
12q24.31
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;
Function
G-protein coupled purinergic nucleotide receptor activity; nicotinic acid receptor activity; receptor activity; signal transducer activity;

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