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Human HCAR2 Stable Cell Line-CHO-K1/Gα15

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Cat.No.
CSC-RG1680
Background
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and(D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis throughG(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid dosesthat are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in matureneutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity ofcAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.
Host Cell
CHO-K1/Gα15
Ship
Dry Ice
Antigen Gene Information
Official Symbol
HCAR2
Synonyms
HCAR2; hydroxycarboxylic acid receptor 2; G protein coupled receptor 109A , GPR109A; HCA2; HM74A; niacin receptor 1; NIACR1; Puma g; PUMAG; nicotinic acid receptor; G protein-coupled receptor 109A; G-protein coupled receptor 109A; G protein-coupled receptor HM74a; G-protein coupled receptor HM74A; hydroxy-carboxylic acid receptor 2; HM74a; HM74b; Puma-g; GPR109A;
GeneID
MIM
UniProt ID
Q8TDS4
Chromosome Location
12q24.31
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;
Function
G-protein coupled purinergic nucleotide receptor activity; nicotinic acid receptor activity; receptor activity; signal transducer activity;

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