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Human HCAR2/Gi/Go Stable Cell Line-CHO

Cat.No.
CSC-RG0544
Abbr
CHO-HuHCAR2/Gi/Go
Alias
HCAR2,GPR109A,HCA2,HM74A,NIACR1,PUMAG,HM74a,HM74b,Puma-g,GPR109A
Growth Properties
Adherent
Host Cell
CHO-K1
Morphology
Epithelial-like
Shipping
Dry ice
Species
Human
Background
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid >acifran >5-methyl nicotinic acid = acipimox >>nicotinuric acid = nicotinamide

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