Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)

Human HCAR2/Galpha15 Stable Cell Line-Chem-4

See other products for HCAR2
Cat.No.
CSC-RG0708
Background
Nicotinic acid (niacin), a vitamin of the B complex, is used clinically in high doses to decrease total plasma levels of cholesterol. Interestingly, the total cholesterol levels and low-density lipoprotein (LDL) concentrations decrease, while the high-density lipoprotein (HDL) concentrations increase with nicotinic acid treatment. The cholesterol-lowering effects of nicotinic acid result from inhibition of lipolysis in adipose tissue, which decreases plasma levels of free fatty acid (FFA). In a study of nicotinic acid and myocardial infarction in the Coronary Drug Project (1966-1975), patients receiving 3 g/day nicotinic acid exhibited reduced rates of myocardial infarction. However, an unwanted effect of high doses of nicotinic acid is vasodilatation, occurring mainly in the upper body and face, known as flushing. Recently two receptors for nicotinic acid have been identified as class A G protein-coupled receptors that couple to Gi to inhibit accumulation of cAMP. GPR109A (also known as HM74A in humans and PUMA-G in mice) is a high affinity receptor for nicotinic acid, whereas GPR109B (also known as HM74) is a low affinity receptor for nicotinic acid that is found in humans but not rodents. GPCR109A is found primarily in adipose tissue and immune cells.
Growth Properties
Adherent
Host Cell
Chem-4
Ship
Dry ice
Gene Information
Official Symbol
HCAR2
Synonyms
HCAR2; hydroxycarboxylic acid receptor 2; G protein coupled receptor 109A , GPR109A; HCA2; HM74A; niacin receptor 1; NIACR1; Puma g; PUMAG; nicotinic acid receptor; G protein-coupled receptor 109A; G-protein coupled receptor 109A; G protein-coupled receptor HM74a; G-protein coupled receptor HM74A; hydroxy-carboxylic acid receptor 2; HM74a; HM74b; Puma-g; GPR109A;
Gene ID
MIM
UniProt ID
Q8TDS4
Chromosome Location
12q24.31
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;
Function
G-protein coupled purinergic nucleotide receptor activity; nicotinic acid receptor activity; receptor activity; signal transducer activity;

Quick Inquiry

Please input "biogene" as verification code.

HCAR2 Related Products

Transfected Stable Cell Lines

By Gene symbol(9)
+Expand
By Species(9)
+Expand

Clones

By Gene symbol(6)
+Expand
By Species(6)
+Expand
By Vector Name(3)
+Expand
By MicroRNA Accession No.(1)
+Expand

Contact Us

USA

Europe

CBpromise   

Our promise to you:
Guaranteed product quality, expert customer support.

24x7 CUSTOMER SERVICE
CONTACT US TO ORDER