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Human GRM8-FLAG Stable Cell Line-HEK293T Galphaqi5

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Cat.No.
CSC-RG0312
Background
The metabotropic glutamate receptors (mGluRs) have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group II and group III mGluRs are linked to the inhibition of the cyclic AMP cascade, but differ in agonist selectivity. Group III agonists include L-2-amino-4-phosphonobutyrate (L-AP4) and L-serine-O-phosphate. The human mGluR8 protein shares 67 to 70% sequence similarity with mGluR4 and mGluR7 and 99% amino acid identity with mouse mGluR8.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T Galphaqi5
Ship
Dry ice
Gene Information
Official Symbol
GRM8
Synonyms
GRM8; glutamate receptor, metabotropic 8; metabotropic glutamate receptor 8; GLUR8; GPRC1H; mGlu8; MGLUR8; FLJ41058; MGC126724;
Gene ID
MIM
UniProt ID
O00222
Chromosome Location
7q31.3-q32.1
Pathway
Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; glutamate receptor activity; group III metabotropic glutamate receptor activity; receptor activity; signal transducer activity;

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