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Human GRM3/Gi Stable Cell Line-CHO

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Cat.No.
CSC-RG0557
Background
Metabotropic glutamate receptor mGluR3 is a G protein-coupled receptor for glutamate. Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and functions to regulate excitability via pre- and postsynaptic mechanisms. The mGluR3 receptor is widely expressed in glial cells but also shows discrete localization both pre- and postsynaptic on glutamatergic and other neurotransmitter synapses. It is also expressed within forebrain regions including hippocampus and thalamus. Agonists of mGluR3 have been shown to suppress enhanced glutamatergic excitations in brain synapses known to be involved in the expression of fear/anxiety in animals and humans. It is anticipated that mGluR3 receptor represent a promising new target for treatment of anxiety and stress-related disorders in humans.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
GRM3
Synonyms
GRM3; glutamate receptor, metabotropic 3; metabotropic glutamate receptor 3; GPRC1C; mGlu3; MGLUR3; glutamate metabotropic receptor 3; GLUR3;
Gene ID
MIM
UniProt ID
Q14832
Chromosome Location
7q21.1-q21.2
Pathway
Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem;
Function
G-protein coupled receptor activity; G-protein coupled receptor activity; calcium channel regulator activity; glutamate receptor activity; group II metabotropic glutamate receptor activity; receptor activity; signal transducer activity;

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