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Human GRM2 Stable Cell Line-CHO-K1/Gα15

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Cat.No.
CSC-RG1687
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.
Host Cell
CHO-K1/Gα15
Ship
Dry Ice
Antigen Gene Information
Official Symbol
GRM2
Synonyms
GRM2; glutamate receptor, metabotropic 2; metabotropic glutamate receptor 2; GPRC1B; mGlu2; MGLUR2; glutamate receptor homolog; glutamate metabotropic receptor 2; GLUR2;
GeneID
MIM
UniProt ID
Q14416
Chromosome Location
3
Pathway
Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem;
Function
G-protein coupled receptor activity; calcium channel regulator activity; glutamate receptor activity; group II metabotropic glutamate receptor activity; receptor activity; signal transducer activity;
Related Products
Cat#
Product Name
Host Cell
Gene Symbol
Species
Price
CSC-RG0567
CHO-K1
GRM2
Human
Cat#
Product Name
Titer
Product Size
Species
Price
AD07166Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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