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Human GPR77/beta-Arrestin Stable Cell Line-CHO

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Cat.No.
CSC-RG1423
Background
The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
GPR77
Synonyms
GPR77; G protein-coupled receptor 77; C5a anaphylatoxin chemotactic receptor C5L2; C5L2; G-protein coupled receptor 77; G protein-coupled receptor C5L2; GPF77;
Gene ID
MIM
UniProt ID
Q9P296
Chromosome Location
19q13.33
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;
Function
C5a anaphylatoxin receptor activity; G-protein coupled receptor activity; receptor activity; signal transducer activity;

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