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Human GPR68 Stable Cell Line-CHO-K1/Gα15

Cat.No.
CSC-RG1663
Host Cell
CHO-K1/Gα15
Shipping
Dry Ice
Source
CHO-K1/Gα15
Species
Human
Subgroup
Human
Background
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulatingcell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulatesinositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fullyactivated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity)
Gene Information
Gene Symbol
GPR68
Synonyms
GPR68; G protein-coupled receptor 68; ovarian cancer G-protein coupled receptor 1; OGR1; G-protein coupled receptor 68; sphingosylphosphorylcholine receptor; ovarian cancer G protein-coupled receptor, 1; GPR12A; MGC111379; MGC156983;
Gene ID
UniProt ID
Q15743
mRNA Refseq
BC069592
Chromosome Location
14q31
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity;
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Osteoclast Signaling, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
MIM

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