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Human GPR119/beta-Arrestin Stable Cell Line-U2OS

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Cat.No.
CSC-RG1519
Background
GPR119 is a GPCR that is predominately expressed in pancreatic beta cells and enteroendocrine cells in the GI tract in humans. Phospholipids and fatty acid amines are possible endogenous ligands, and oleylethanolamide is one of the more potent ligands known. Agonists of GPR119 elevate cyclic AMP levels in cell models which can potentiate glucose-stimulated insulin secretion. In mice, it has been showed that a GPR119 agonist stimulated the release of both GLP-1 and GIP in wildtype, but not GPR119-deficient animals. GPR119 agonists also improve glycaemic control for mice in vivo, and GLP-1 administration reduces food intake and results in weight loss in humans. Taken together, these data suggest that GPR119 could be an important target for therapeutic management of diabetes and obesity in humans.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
U2OS
Ship
Dry ice
Gene Information
Official Symbol
GPR119
Synonyms
GPR119; G protein-coupled receptor 119; glucose-dependent insulinotropic receptor; GPCR2; hGPCR2; G-protein coupled receptor 2; G-protein coupled receptor 119; MGC119957;
Gene ID
MIM
UniProt ID
Q8TDV5
Chromosome Location
Xq26.1
Pathway
Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem; Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem; Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), organism-specific biosystem;
Function
G-protein coupled receptor activity; lipid binding; receptor activity; signal transducer activity;

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