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Human GPBAR1/Clytin Stable Cell Line-HEK293

See other products for GPBAR1
Cat.No.
CSC-RG0617
Background
The bile acid lithocolic acid acts as an agonist on the GPBA GPCR, also known as GPR131 or TGR5, to increase intracellular cAMP in cells that express the receptor. Bile acids and other GPBA ligands increase glucagon-like peptide-1 (GLP-1) secretion from intestinal cells. Although Type II diabetics have impaired ability to secrete GLP-1, their responsiveness to this compound, which enhances the effects of insulin, is normal. Thus GPBA agonists are of interest in developing therapeutics for diabetes. Interestingly, it has been suggested that the anti-diabetic effect of olive leaves could in part be mediated by agonist activity at GPBA receptors by oleanolic acid.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
GPBAR1
Synonyms
GPBAR1; BG37; GPCR19; GPR131; M-BAR; TGR5; G protein-coupled bile acid receptor 1; G-protein coupled bile acid receptor 1; hBG37; hGPCR19; membrane bile acid receptor; G-protein coupled receptor GPCR19; membrane-type receptor for bile acids; G-protein coupled bile acid receptor BG37
Gene ID
MIM
UniProt ID
Q8TDU6
Chromosome Location
2q35
Pathway
Class A/1 (Rhodopsin-like receptors); GPCR ligand binding; Signal Transduction; Signal by GPCR; G alpha (s) signalling events; GPCR downstream signaling
Function
G-protein coupled receptor activity
Related Products
Cat#
Product Name
Host Cell
Gene Symbol
Species
Price
CSC-SC006480
HEK293 ,CHO, etc.
GPBAR1
Human
CSC-RG1650
CHO-K1
GPBAR1
Human
CSC-DC006480
HEK293 ,Hela, etc.
GPBAR1
Human
Cat#
Product Name
Titer
Product Size
Species
Price
AD06969Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human

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