Gonadotropin-releasing hormone receptor (GnRHR) is a receptor for gonadotropin-releasing hormone (GnRH), also known as luteinizing hormonereleasing hormone (LHRH) and prolactin release-inhibiting factor (PIF). GnRHR is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Gametes and preimplantation embryos also express GnRH and GnRHR. Binding of GnRH to GnRHR causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from gonadotropic cells of the anterior pituitary. Mutations in GnRHR may cause hypogonadotropic hypogonadism and may be associated with anosmia.