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Human GNRH1/Galpha15 Stable Cell Line-Chem-1

Cat.No.
CSC-RG0674
Abbr
Chem-1-HuGNRH1/Galpha15
Alias
GNRH,GRH,HH12,LHRH,LNRH
Growth Properties
Adherent
Host Cell
Chem-1
Shipping
Dry ice
Background
Gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone (LHRH), regulates the reproductive hormonal cascade in vertebrates. Upon release from the hypothalamus, GnRH stimulates secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary. In humans, the type I GnRH receptor is a GPCR that is unusual in the lack of a cytoplasmic C-terminal tail. Although some species contain a type II GnRH receptor, the human version of this second receptor appears to contain mutations that render it inactive. GnRH analogs (agonists) are used in low doses in a pulsatile fashion in the treatment of infertility, delayed puberty and cryptorchidism. GnRH agonists at high doses desensitize the receptor, and are used along with antagonists in the treatment of hormone-dependent diseases.

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