GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member related to glucagon receptor and GLP1 receptor. Glucagon like peptide 2 receptor is expressed in SNC and gut. GLP2R transduces the biological actions of GLP-2, a 33 aminoacid peptide produced by the intestinal endocrine L cell and by various neurons in the central nervous system. Intestinal GLP-2 is co-secreted along with GLP-1 upon nutrient ingestion. GLP-2 produces several actions such as including intestinal growth, enhancement of intestinal function, reduction in bone breakdown and neuroprotection.