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Human GLP1R/Galpha15 Stable Cell Line-Chem-9

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Cat.No.
CSC-RG0665
Background
Glucagon-like peptide-I (GLP-1), part of the secretin peptide family, is a class B (class 2) receptor and is involved in glucose-dependent insulin secretion. Insulin secretion is predominantly controlled by glucose levels in the blood, however glucagon stimulates the secretion of insulin. The GLP-1 receptor is coupled to Gs resulting in increased cAMP levels. GLP-1 has been shown to have an affect in delayed gastric emptying and appetite regulation. Due to the involvement in insulin secretion GLP-1 has been identified as a therapeutic target in type II diabetes.
Growth Properties
Adherent
Host Cell
Chem-9
Ship
Dry ice
Gene Information
Official Symbol
GLP1R
Synonyms
GLP1R; glucagon-like peptide 1 receptor; GLP-1R; GLP-1-R; GLP-1 receptor; MGC138331;
Gene ID
MIM
UniProt ID
P43220
Chromosome Location
6p21
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Glucagon-type ligand receptors, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem;
Function
G-protein coupled peptide receptor activity; glucagon receptor activity; peptide hormone binding; receptor activity; signal transducer activity; transmembrane signaling receptor activity;

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