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Human GLP1R/Galpha15 Stable Cell Line-CHO

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Cat.No.
CSC-RG0667
Background
Glucagon-like peptide-I (GLP-1), a member of the glucagon-secretin peptide family, is secreted from L-cells of the small intestine and binds to a class B (class 2) G protein-coupled receptor. The GLP-1 receptor is expressed in pancreatic beta cells and upon binding to GLP-1, it couples to Gs to increase cAMP levels and insulin secretion. In addition, GLP-1 has been shown to delay gastric emptying and regulate appetite. Therefore, the GLP-1 receptor represents an important therapeutic target for type II diabetes, and a degradation-resistant analog of GLP-1, exanatide, is used clinically in combination with other glucose-lowering drugs to control type II diabetes.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO
Ship
Dry ice
Gene Information
Official Symbol
GLP1R
Synonyms
GLP1R; glucagon-like peptide 1 receptor; GLP-1R; GLP-1-R; GLP-1 receptor; MGC138331;
Gene ID
MIM
UniProt ID
P43220
Chromosome Location
6p21
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Glucagon-type ligand receptors, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem;
Function
G-protein coupled peptide receptor activity; glucagon receptor activity; peptide hormone binding; receptor activity; signal transducer activity; transmembrane signaling receptor activity;

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