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Human GIPR/Galpha15 Stable Cell Line-Chem-9

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Cat.No.
CSC-RG0664
Background
Gastric inhibitory polypeptide receptor (GIP) has been identified in the glucose-mediated secretion of insulin. GIP is in the secretin/VIP receptor family which includes secretin, VIP, glucagon, GLP-1, growth hormone releasing hormone (GHRH), and PACAP. GIP is secreted after meal ingestion has been shown to stimulate bone formation resulting in lower occurrences of osteoporosis. Type 2 diabetes is a result of decreased glucose-stimulated insulin secretion which makes insulin secretion potentiators a popular target for diabetes treatments, it is thought that a defect in GIP expression and/or signaling may lead to beta-cell dysfunction and type 2 diabetes.
Growth Properties
Adherent
Host Cell
Chem-9
Ship
Dry ice
Gene Information
Official Symbol
GIPR
Synonyms
GIPR; gastric inhibitory polypeptide receptor; GIP-R; glucose-dependent insulinotropic polypeptide receptor; PGQTL2; MGC126722;
Gene ID
UniProt ID
P48546
Chromosome Location
19q13.2-q13.3
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Glucagon-type ligand receptors, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
gastric inhibitory peptide receptor activity; peptide hormone binding; receptor activity; signal transducer activity; transmembrane signaling receptor activity;

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