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Human GHSR/beta-Arrestin Stable Cell Line-U2OS

Cat.No.
CSC-RG1503
Abbr
U2OS-HuGHSR/beta-Arrestin
Alias
GHSR,GHRP,GHS-R
Growth Properties
Adherent
Host Cell
U2OS
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.

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