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Human GHSR/Galpha15 Stable Cell Line-Chem-1

See other products for GHSR
Cat.No.
CSC-RG0663
Background
Ghrelin is a 28 amino acid peptide, containing a unique octanoyl moiety added post-translationally to Ser3, with diverse activities in the CNS, gastrointestinal tract, and cardiovascular system. In the CNS, ghrelin stimulates release of growth hormone from the anterior pituitary and increases appetite by binding to neurons within the arcuate nucleus. Circulating concentrations of ghrelin increase with preprandially and decrease post-prandially, and thus counterbalances the effects of leptin to coordinate energy balance, appetite and food intake. Ghrelin is also expressed in the cardiovascular system where it acts as a potent vasodilator; receptors are up-regulated in patients with atherosclerosis, suggesting that it plays a role in compensating for increased vasoconstriction. The effects of ghrelin are mediated by a Gq-coupled receptor, originally designated GHSR (growth hormone secretogogue receptor), and more recently termed the Ghrelin Receptor or GRLN. Two splice variants have been described; type 1a (GHS-R1a) is the functional receptor, whereas type 1b (GHS-R1b) encodes a truncated, inactive protein with only 5 transmembrane domains. As administration of agonists of the ghrelin receptor to rats leads to increased food intake and antagonists reduce food intake, antagonism and inverse agonism of the ghrelin receptor may reduce food intake in certain types of obesity, and agonists of the ghrelin receptor are potentially useful for treatment of anorexia and cachexia.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
GHSR
Synonyms
GHSR; growth hormone secretagogue receptor; growth hormone secretagogue receptor type 1; GHRP; GHS-R; ghrelin receptor; GH-releasing peptide receptor;
Gene ID
MIM
UniProt ID
Q92847
Chromosome Location
3q26.31
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; growth hormone secretagogue receptor activity; growth hormone-releasing hormone receptor activity; peptide hormone binding; receptor activity; signal transducer activity;
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Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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