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Human GCGR-FLAG Stable Cell Line-HEK293T

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Cat.No.
CSC-RG0442
Background
The human glucagon receptor GCGR mediates the action of the pancreatic peptide hormone glucagon. Glucagon regulates blood glucose via control of hepatic glycogenolysis and gluconeogenesis and via regulation of insulin release from the beta cell. Type 2 diabetes is characterized by inappropriate regulation of hepatic glucose production, which is due to an imbalance in the bihormonal relationship between plasma levels of glucagon and insulin. The glucose-lowering effects of glucagon peptide antagonists and anti-glucagon antibodies have demonstrated the potential of glucagon receptor antagonism as a treatment for type 2 diabetes. Glucagon also elicits various effects in extrahepatic tissues, including adipose tissue, kidney, heart, pancreatic beta cells, gastrointestinal tract, thyroid and central nervous system.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T
Ship
Dry ice
Gene Information
Official Symbol
GCGR
Synonyms
GCGR; glucagon receptor; GGR; GL-R; FLJ97182; MGC138246;
Gene ID
MIM
UniProt ID
P47871
Chromosome Location
17q25
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Glucagon signaling in metabolic regulation, organism-specific biosystem;
Function
glucagon receptor activity; guanyl-nucleotide exchange factor activity; peptide hormone binding; receptor activity; signal transducer activity;

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