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Human GALR1/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1279
Background
Galanin is a 29-30 amino acid peptide originally purified from intestine but later found to be abundant in the CNS. A family of 3 GPCRs, GAL1, GAL2 and GAL3, bind to galanin and mediate its biological effects. GAL1 couples to Gi/o to decrease intracellular cAMP levels. Galanin and its receptors have been implicated in pain, cognition, seizure activity, depression and drug addiction. In particular, GAL1 mediates the anticonvulsant activity of galanin; mice lacking GAL1 are affected by spontaneous seizures, and have increased susceptibility to seizures induced by lithium-pilocarpine treatment and electrical perforant path stimulation.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
GALR1
Synonyms
GALR1; galanin receptor 1; GALNR, GALNR1; galanin receptor type 1; GAL1-R; GALR-1; GALNR; GALNR1;
Gene ID
MIM
UniProt ID
P47211
Chromosome Location
18q23
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; galanin receptor activity; neuropeptide binding; receptor activity; signal transducer activity;

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