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Human FPR1 Stable Cell Line-CHO Galpha16

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Cat.No.
CSC-RG0843
Background
The FPR1, FPRL1 and FPRL2 receptors belongs to a family of receptors that all respond to N-formyl peptides. N-Formyl peptides are bacterial peptides which induce chemotaxis in neutrophils and other phagocytic cells to sites of bacterial infection. This cell line allows FPR1 to couple to the intracellular signaling pathway through Ga16, and should be useful for screening compounds for activity as modulators of host defense mechanisms against bacterial infection and in the regulation of inflammatory responses.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1 Galpha16
Stability
At least 6 passages
Ship
Dry ice
Gene Information
Official Symbol
FPR1
Synonyms
FPR1; formyl peptide receptor 1; fMet-Leu-Phe receptor; FMLP; FPR; fMLP receptor; N-formylpeptide chemoattractant receptor;
Gene ID
MIM
UniProt ID
P21462
Chromosome Location
19q13.41
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; N-formyl peptide receptor activity; receptor activity; signal transducer activity;

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