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Human FFAR1-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0250
Background
G-protein coupled receptor 40 (GPR40 or FFA1) is specifically expressed in brain and pancreas. In pancreas, abundant GPR40 is localized to insulin-producing beta cells. Long-chain FFAs amplify glucose-stimulated insulin secretion from pancreatic beta cells by activating GPR40, indicating that GPR40 agonists and/or antagonists have potential for the development of new anti-diabetic drugs. GPR40 overexpression in breast cancer cells amplified oleate-induced proliferation, whereas silencing the GPR40 gene decreased it. These results suggest that GPR40 is implicated in the control of breast cancer cell growth by fatty acids and that GPR40 may provide a link between fat and cancer.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
FFAR1
Synonyms
FFAR1; free fatty acid receptor 1; G protein coupled receptor 40 , GPR40; FFA1R; G protein-coupled receptor 40; G-protein coupled receptor 40; GPR40; GPCR40;
Gene ID
MIM
UniProt ID
O14842
Chromosome Location
19q13.1
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Free fatty acid receptors, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem;
Function
G-protein coupled receptor activity; fatty acid binding; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;

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