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Human FFAR1/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1277
Background
GPR40 is a member of the free fatty acid G protein coupled receptor family and is activated by saturated and unsaturated carboxylic acids with carbon chain lengths greater than six. Expression analysis shows that GPR40 is specifically expressed in brain and in insulin-producing beta cells in the pancreas. Activation of GPR40 by long-chain fatty acids has been shown to amplify glucose-stimulated insulin secretion, suggesting that GPR40 may represent an important target for drugs that regulate diabetes. GPR40 has also been shown to be overexpressed in breast cancer cells, where it may regulate cell growth.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
FFAR1
Synonyms
FFAR1; free fatty acid receptor 1; G protein coupled receptor 40 , GPR40; FFA1R; G protein-coupled receptor 40; G-protein coupled receptor 40; GPR40; GPCR40;
Gene ID
MIM
UniProt ID
O14842
Chromosome Location
19q13.1
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Free fatty acid receptors, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem;
Function
G-protein coupled receptor activity; fatty acid binding; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;

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