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Human F2R/beta-Arrestin Stable Cell Line-CHO

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Cat.No.
CSC-RG1491
Background
PAR1 is one of the four members of G protein-coupled proteaseactivated receptor family (PAR1, PAR2, PAR3, and PAR4). PAR1 is activated by coagulant protease thrombin via an irreversible proteolytic mechanism: thrombin specifically cleaves the extracellular N-termini of the receptor to unmask a new amino acid terminus, which in turn acts as a peptide ligand by binding intramolecularly to the body of the receptor. An increased thrombin generation and PAR1 expression are observed on cells within atherosclerotic plaque and thrombus and following vascular injury. PAR1 may play important role in thrombosis and restenosis and thus a PAR1 antagonist possesses the therapeutic potential in treating these diseases.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
F2R
Synonyms
F2R; coagulation factor II (thrombin) receptor; proteinase-activated receptor 1; CF2R; PAR 1; PAR1; TR; thrombin receptor; protease-activated receptor 1; coagulation factor II receptor; HTR; PAR-1;
Gene ID
MIM
UniProt ID
P25116
Chromosome Location
5q13
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Endocytosis, organism-specific biosystem;
Function
G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; G-protein coupled receptor activity; protein binding; receptor activity; receptor binding; signal transducer activity; thrombin receptor activity;

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