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Human EDNRB/Galpha15 Stable Cell Line-CHO

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Cat.No.
CSC-RG0656
Background
The endothelin family of peptides are potent vasoconstrictors synthesized by endothelial cells in both constitutive and inducible pathways. The biological actions of endothelins are mediated by two GPCRs, ETA and ETB. Whereas ETA is the predominant receptor on smooth muscle cells and thus is the primary mediator of the vasoconstrictor activity, ETB is found on endothelial cells and mediates vasodilation. In addition, ETB has also been linked to renal failure, congestive heart failure, atherosclerosis, and pulmonary hypertension. A mutation in ETB has been found to cause Hirschsprung disease-2, a degenerative disease of the digestive tract.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO
Ship
Dry ice
Gene Information
Official Symbol
EDNRB
Synonyms
EDNRB; endothelin receptor type B; HSCR, HSCR2; endothelin B receptor; ETB; endothelin receptor non-selective type; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2;
Gene ID
MIM
UniProt ID
P24530
Chromosome Location
13q22
Pathway
Arf6 trafficking events, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Endothelins, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; endothelin receptor activity; endothelin receptor activity; endothelin receptor activity; peptide hormone binding; receptor activity; signal transducer activity;

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