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Human EDNRA-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0241
Background
Endothelin is a hormone produced predominantly by endothelial cells that have been recognized to play a significant role in the development of several cardiovascular disease states. Its receptor ETA has been reported in a variety of tissues including placenta, uterus, testis, heart, adrenal gland, lung, kidney, ovary, skin, liver, bladder, large blood vessels, cerebellum, neurons, and meningioma tumor cells. In the vasculature, ETA receptors residing on smooth muscle cells mediate prolonged vasoconstriction. Furthermore, activation of the ETA mediates events that regulate mitogenesis, apoptosis, angiogenesis and metastasis in tumors. The Human EDNRA-FLAG stable cell lines-CHO expresses EDNRA cDNA that is identical to GenBank NM_001957.1 except for 1 mutation that results in a change in amino acid Leu to Val at position 322, which has been reported as a natural variant.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
EDNRA
Synonyms
EDNRA; endothelin receptor type A; endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor; ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR;
Gene ID
MIM
UniProt ID
P25101
Chromosome Location
4
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; EGFR-dependent Endothelin signaling events, organism-specific biosystem; Endothelins, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; endothelin receptor activity; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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