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Human DRD5/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0654
Background
Dopamine is a catecholamine neurotransmitter that functions in the CNS to control locomotor, cognitive, emotional and neurendocrine processes, and in the periphery to modulate cardiovascular, renal and gastrointestinal processes. The biological activities of dopamine are mediated by a family of five GPCRs. The D1 and D5 subtypes couple to Gs to increase intracellular cAMP, whereas the D2, D3 and D4 subtypes couple to Gi to reduce cAMP. The hypertensive phenotype of mice with a targeted deletion of D5 indicates that D5 regulates central control of sympathetic vascular tone. In addition, D5 modulates locomotion and corticostriatal long-term depression.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
DRD5
Synonyms
DRD5; dopamine receptor D5; DRD1L2; D(1B) dopamine receptor; DRD1B; dopamine D5 receptor; dopamine receptor D1B; d dopamine receptor; D1beta dopamine receptor; DBDR; MGC10601;
Gene ID
UniProt ID
P21918
Chromosome Location
4p16.1
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Dopamine receptors, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem;
Function
G-protein alpha-subunit binding; G-protein coupled receptor activity; dopamine binding; dopamine receptor activity; dopamine receptor activity, coupled via Gs; drug binding; receptor activity; signal transducer activity;

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