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Human DRD4/Galpha15 Stable Cell Line-Chem-5

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Cat.No.
CSC-RG0653
Background
The neurotransmitter dopamine is involved in a wide variety of neuroendocrine, emotional, cognitive and locomotor functions. These activities of dopamine are mediated by a group of 5 G protein coupled receptors, 2 of which (D1 and D5) couple to Gs and 3 of which (D2 , D3 , D4) couple to Gi. The D4 receptor is highly polymorphic, particularly in the third cytoplasmic loop, which contains from 2 to 7 repeats of 16 amino acids. Individuals with 7 repeats have increased risk of developing ADHD. Mice engineered to lack D4 have reduced locomotor activity, increased sensitivity to drugs of abuse that elevate dopamine (cocaine, methamphetamine and ethanol), and reduced response to novelty.
Growth Properties
Adherent
Host Cell
Chem-5
Ship
Dry ice
Gene Information
Official Symbol
DRD4
Synonyms
DRD4; dopamine receptor D4; D dopamine receptor; dopamine D4 receptor; D(2C) dopamine receptor; seven transmembrane helix receptor; D4DR;
Gene ID
MIM
UniProt ID
P21917
Chromosome Location
11p15.5
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Dopamine receptors, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; SH3 domain binding; dopamine binding; dopamine receptor activity; dopamine receptor activity, coupled via Gi/Go; dopamine receptor activity, coupled via Gi/Go; drug binding; potassium channel regulator activity; protein binding; receptor activity; signal transducer activity;

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