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Human DRD2/Galpha15 Stable Cell Line-CHO

See other products for DRD2
Cat.No.
CSC-RG0652
Background
Dopamine is a catecholamine neurotransmitter that functions in the CNS to control locomotor, cognitive, emotional and neurendocrine processes, and in the periphery to modulate cardiovascular, renal and gastrointestinal processes. The biological activities of dopamine are mediated by a family of five GPCRs. The D1 and D5 subtypes couple to Gs to increase intracellular cAMP, whereas the D2 , D3 and D4 subtypes couple to Gi to reduce cAMP. The D2 dopamine receptors have been of particular clinical interest due to their regulation of prolactin secretion and their affinity for antipsychotic drugs. The D2 receptor exists as two alternatively spliced isoforms differing in the insertion of a stretch of 29 amino acids in the third intracellular loop (D2S and D2L).
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO
Ship
Dry ice
Gene Information
Official Symbol
DRD2
Synonyms
DRD2; dopamine receptor D2; D dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor; D2R; D2DR;
Gene ID
MIM
UniProt ID
P14416
Chromosome Location
11q22-q23
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; Dopamine receptors, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem;
Function
G-protein coupled receptor activity; dopamine binding; dopamine receptor activity, coupled via Gi/Go; dopamine receptor activity, coupled via Gi/Go; drug binding; drug binding; ionotropic glutamate receptor binding; potassium channel regulator activity; protein binding; receptor activity; receptor binding; signal transducer activity;
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AD00047Z
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Human
AD05093Z
>1x 10^9 vp/ml
1 x 0.2 ml
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