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Human DRD1/Galpha15 Stable Cell Line-Chem-7

Cat.No.
CSC-RG0651
Abbr
Chem-7-HuDRD1/Galpha15
Alias
DRD1,DADR,DRD1A
Growth Properties
Adherent
Host Cell
Chem-7
Shipping
Dry ice
Species
Human
Background
Dopamine is a catecholamine neurotransmitter that functions in the CNS to control locomotor, cognitive, emotional and neurendocrine processes, and in the periphery to modulate cardiovascular, renal and gastrointestinal processes. The biological activities of dopamine are mediated by a family of five GPCRs. The D1 and D5 subtypes couple to Gs to increase intracellular cAMP, whereas the D2 , D3 and D4 subtypes couple to Gi to reduce cAMP. The D2 dopamine receptors have been of particular clinical interest due to their regulation of prolactin secretion and their affinity for antipsychotic drugs. The D2 receptor exists as two alternatively spliced isoforms differing in the insertion of a stretch of 29 amino acids in the third intracellular loop (D2S and D2L ).

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