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Human CXCR6/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1268
Background
The GPCR CXCR6 (previously known as BONZO, STRL33 and TYMSTR) binds selectively to the free chemokine domain of CXCL16, which is derived from a membrane-bound precursor containing a CXC-containing chemokine domain, a glycosylated mucin-like domain, and a transmembrane domain. CXCR6 is selectively expressed on Th1, Th2 and Tr1 T cell subsets, whereas CXCL16 is expressed on monocytes/macrophages and dendritic cells. CXCR6 functions as a cofactor with CD4 for HIV entry and Env-mediated cell fusion. Binding of CXCL16 to CXCR6 promotes migration of activated lymphocytes to sites of inflammation in tissues such as liver and synovium.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
CXCR6
Synonyms
CXCR6; chemokine (C-X-C motif) receptor 6; C-X-C chemokine receptor type 6; BONZO; CD186; STRL33; TYMSTR; CDw186; CXC-R6; CXCR-6; G protein-coupled receptor; G-protein coupled receptor bonzo; G-protein coupled receptor STRL33;
Gene ID
MIM
UniProt ID
O00574
Chromosome Location
3p21
Pathway
Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function
C-X-C chemokine receptor activity; G-protein coupled receptor activity; coreceptor activity; receptor activity; signal transducer activity;

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