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Human CXCR3/Clytin Stable Cell Line-HEK293

See other products for CXCR3
Cat.No.
CSC-RG0641
Background
CXCR3 is a 7-TM GPCR that is selective for the CXC chemokines IP10, I-TAC and MIG. Binding of IP10 and MIG to CXCR3 induces Ca2+ mobilization, chemotaxis and inflammatory responses of T lymphocytes, and also act as potent inhibitors of angiogenesis. CXCR3 is highly expressed in IL-2-activated T lymphocytes in vitro, and in T lymphocytes present in inflamed tissues in rheumatoid arthritis and multiple sclerosis. In vivo, neutralization of CXCR3 inhibits experimentally induced type I diabetes, peritonitis, and post-lung transplantation bronchiolitis obliterans syndrome.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
CXCR3
Synonyms
CXCR3; chemokine (C-X-C motif) receptor 3; G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor; GPR9; CD182; Mig-R; CKR-L2; IP10-R;
Gene ID
MIM
UniProt ID
P49682
Chromosome Location
Xq13
Pathway
CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function
C-X-C chemokine receptor activity; G-protein coupled receptor activity; chemokine binding; chemokine receptor activity; receptor activity; signal transducer activity;
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Cat#
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AD04437Z
>1x 10^9 vp/ml
1 x 0.2 ml
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