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Human CXCR1/beta-Arrestin Stable Cell Line-U2OS

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Cat.No.
CSC-RG1461
Background
CXCR1 is a high affinity interleukin-8 receptor (IL-8RA). Binding of IL-8 to the receptor causes activation of neutrophils. Neutrophils have been implicated in the pathogenesis of many inflammatory lung diseases, including acute respiratory distress
syndrome, chronic obstructive pulmonary disease, and asthma. Antagonists of CXCR1 may block in vivo trafficking of neutrophils, suggesting that antagonism of IL-8 at the receptor level is a viable therapeutic strategy. The Human CXCR1-FLAG stable cell lines-HEK293T expresses IL8RA cDNA that is identical to GenBank NM_000634.2 except for 2 missense mutations, Met→Arg at position 31 and Arg→Cys at position 335. Both have been reported to be natural variants.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
U2OS
Ship
Dry ice
Gene Information
Official Symbol
CXCR1
Synonyms
CXCR1; chemokine (C-X-C motif) receptor 1; CMKAR1, IL8RA, interleukin 8 receptor, alpha; C-X-C chemokine receptor type 1; CD181; CDw128a; CKR 1; CXC-R1; CXCR-1; IL-8R A; IL-8 receptor type 1; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A; high affinity interleukin-8 receptor A; C-C; CD128; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; C-C-CKR-1;
Gene ID
MIM
UniProt ID
P25024
Chromosome Location
2q35
Pathway
Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem;
Function
G-protein coupled receptor activity; chemokine receptor activity; interleukin-8 binding; interleukin-8 receptor activity; receptor activity; signal transducer activity;

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