CXCR1 is a high affinity interleukin-8 receptor (IL-8RA). Binding of IL-8 to the receptor causes activation of neutrophils. Neutrophils have been implicated in the pathogenesis of many inflammatory lung diseases, including acute respiratory distress syndrome, chronic obstructive pulmonary disease, and asthma. Antagonists of CXCR1 may block in vivo trafficking of neutrophils, suggesting that antagonism of IL-8 at the receptor level is a viable therapeutic strategy. The Human CXCR1-FLAG stable cell lines-HEK293T expresses IL8RA cDNA that is identical to GenBank NM_000634.2 except for 2 missense mutations, Met→Arg at position 31 and Arg→Cys at position 335. Both have been reported to be natural variants.