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Human CRHR2/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0649
Background
The corticotropin-releasing factor receptors, CRF1 and CRF2, are Gs-coupled GPCRs expressed in the brain, blood vessels and intestine that bind to several neuropeptides, including corticotropin-releasing factor (CRF) and urocortin, and the amphibian peptide sauvagine. In addition, two peptides, urocortin II (Ucn II) and urocortin III (Ucn III), bind selectively and with high affinity to CRF2. The CRF peptides and their receptors play important roles in stress mediated by the hypothalamic-pituitary-adrenal axis in animal models, and possibly in depression and anxiety in humans, although the contributions of CRF1 and CRF2 appear to be distinct. In addition, CRF1 and CRF2 differentially alter feeding behavior, gastric motility and vascular tone.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
CRHR2
Synonyms
CRHR2; corticotropin releasing hormone receptor 2; corticotropin-releasing factor receptor 2; CRF RB; CRF2; HM CRF; CRH-R2; CRF2 receptor, beta isoform; CRFR2; CRF-RB; HM-CRF;
Gene ID
MIM
UniProt ID
Q13324
Chromosome Location
7p21-p15
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
corticotrophin-releasing factor receptor activity; protein binding; receptor activity; signal transducer activity;

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