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Human CRHR1-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0270
Background
Human secretin receptor (gene name SCTR) is a G-protein-coupled receptor, a member of the class B GPCR subfamily. Secretin receptor binds to peptide secretin and the pituitary adenylate cyclase activating peptide. It was the first receptor that was cloned in the class B family of GPCRs. Secretin receptor is also regulated by peptide hormones from the glucagon hormone family. The receptor activates two distinct intracellular signaling pathways, i.e. the adenyl cyclase and the phosphatidyl-inositol calcium pathways. Northern blot analysis has shown that the secretin receptor is expressed in pancreas, kidney, small intestine, lung, liver, and in trace levels in the brain, heart and ovary. Secretin-receptor mRNA is abundant in all gastrinomas, enriched in one specific variant. Knockout of secretin receptor was shown to reduce large cholangiocyte hyperplasia. Studies have also demonstrated the potential use of secretin as a therapy for ductopenic liver diseases.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
CRHR1
Synonyms
CRHR1; corticotropin releasing hormone receptor 1; CRHR; corticotropin-releasing factor receptor 1; corticotropin releasing factor receptor; CRF R; CRF1; seven transmembrane helix receptor; corticotropin-releasing hormone receptor 1; corticotropin-releasing factor type 1 receptor; corticotropin releasing hormone receptor variant 1e; corticotropin releasing hormone receptor variant 1g; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRHR1f; CRF-R-1; CRH-R-1; CRH-R1h;
Gene ID
MIM
UniProt ID
P34998
Chromosome Location
17q12-q22
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Long-term depression, organism-specific biosystem; Long-term depression, conserved biosystem;
Function
corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone binding; peptide binding; protein binding; receptor activity; signal transducer activity;

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