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Human CMKLR1/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0626
Background
ChemR23 was discovered as an orphan receptor related to the chemoattractant receptors C3a, C5a and FPR1, and expressed on dendritic cells and macrophages. A ligand for ChemR23 was characterized as chemerin, a 15 kD proteolytically processed protein found in inflammatory sites; a 9 amino acid peptide from the C-terminus of chemerin is sufficient to activate ChemR23. Chemerin expressed in lymphoid and microvascular endothelium mediates migration of ChemR23-expressing dendritic cells to lymphoid organs and vasculature at sites of inflammation. In addition, a bioactive lipid, resolvin E1, was found to functionally interact with ChemR23 to reduce inflammation.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
CMKLR1
Synonyms
CMKLR1; chemokine-like receptor 1; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez; DEZ; ChemR23; CHEMERINR; MGC126105; MGC126106;
Gene ID
MIM
UniProt ID
Q99788
Chromosome Location
12q24.1
Pathway
GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled receptor activity; chemokine receptor activity; protein binding; receptor activity; signal transducer activity;

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