Tel: 1-631-626-9181 (USA)   44-208-144-6005 (Europe)
  Email:

Human CHRM5/Apoaequorin Stable Cell Line-CHO

Cat.No.
CSC-RG1233
Abbr
CHO-HuCHRM5/Apoaequorin
Alias
CHRM5,HM5,MGC41838
Growth Properties
Adherent
Host Cell
CHO-K1
Morphology
Epithelial-like
Shipping
Dry ice
Species
Human
Background
The muscarinic M5 receptor is a 532-amino acid 7-transmembrane protein. Acetylcholine, a potent dilator of most vascular beds, virtually lost the ability to dilate cerebral arteries and arterioles in M5 -/- mice, suggesting that endothelial M5 receptors mediate this activity in wild-type mice. M5 receptors located on dopaminergic nerve terminals play a role in facilitating muscarinic agonist-induced dopamine release in the striatum. Both somatic and affective components of naloxone-induced morphine withdrawal symptoms were significantly attenuated in M5 -/- mice. M5 receptor activity modulates both morphine reward and withdrawal processes, suggesting that M5 receptors may represent a novel target for the treatment of opiate addiction.
For research use only. Not intended for any clinical use.

Quick Inquiry

Verification code