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Human CHRM4/Galpha15 Stable Cell Line-Chem-4

See other products for CHRM4
Cat.No.
CSC-RG0598
Background
The muscarinic acetylcholine receptor (mAChR) family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. The M1, M3 and M5 receptors couple to Gq to mobilize intracellular calcium, whereas the M2 and M4 receptors couple to Gi/o to inhibit cAMP production. Muscarinic M4 receptor is known to be abundantly expressed in the striatum. Consistent with this fact, locomotor activity was significantly increased in M4 receptor-deficient mice.
Growth Properties
Adherent
Host Cell
Chem-4
Ship
Dry ice
Gene Information
Official Symbol
CHRM4
Synonyms
CHRM4; cholinergic receptor, muscarinic 4; muscarinic acetylcholine receptor M4; acetylcholine receptor; muscarinic 4; acetylcholine receptor, muscarinic 4; HM4; M4R;
Gene ID
MIM
UniProt ID
P08173
Chromosome Location
11p12-p11.2
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;
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